Nos tutelles

CNRS

Nos partenaires

Rechercher




Accueil > EN > Research Areas > Complex Systems Dynamics > BIological Systems > Cellular stress response

Cellular stress response

par Emmanuel COURTADE, François ANQUEZ, Webmestre - publié le , mis à jour le

Cells are continously subjected to damages of macromolecules (DNA, lipids or proteins), the so-called cellular stress. Macromolecules are crucial and cells have developed molecular networks to detect injury and maintian their integrity. While biochemical pathways involved in stress response have been thoroughly described, the dynamics of these operations and their interplay with other major cellular functions are poorly understood. Our group combines multiple scientific expertises at the crossroad of physics, chemistry and biology (biophotonics, photo-chemistry, mathematical modelling, microfluidics, cell/molecular biology, biochemistry) in order to better understand how cells orchestrate in space and time such stress response. Our motivations range from basic understanding of the design of cellular function in the search of novel anticancerous therapeutic outcomes.

In our early studies we have developed optical methods based on infrared laser radiation to induce a tightly controlled oxydative and/or thermal perturbation to cells. We also developed custom made incubators with optical access to maintain cells under physiological conditions while observed with time-lapse microscopy. All together these methods allows us to monitor the kinetics of biochemical events upon time varying stimulation at time scales ranging from one ten’s of a second to several hours. These data in hand we try to build a mathematical representation that is intented to describe the system and to help us understand its design.

Our research focuses on :

Collaborations

Ikram El Yazidi Belkoura
Glycobiologie de la signalisation cellulaire et des glycopathologies
Unité de glycobiologie structurale et fonctionnelle - Université Lille 1, France

Anthony Treizebre, Alexi Vlandas and Vincent Senez
BioMEMS
IEMN - Université Lille 1, France

Valérie Mezger and Délara Sabéran-Djoneidi
Development and environment interface
UMR 7216 « Épigénétique et Destin Cellulaire - Université Paris-Diderot, France

Contact

Open position

A post-doc position is available to work on the computational/mathematical modeling aspect of the cellular stress response project.